In 1892, the German scientist and father of immunology Paul Ehrlich published a study on mice through passive immunization of their milk can make their young mice gain resistance to disease, this is the "maternal immunity" theory. He believes this is also true for humans, using the term "Immune Milk" for the first time to describe the milk of mammals that have been specifically immunized.

In 1950, Dr. William Petersen, a famous dairy scientist reintroduced the concept of immune milk. Petersen pointed out that the connective tissue of bovine breasts contains antibody-producing cells. When injected into cow breasts with inactivated bacteria, specific antibodies are found in the milk, supporting previous studies conclusions. Therefore, Petersen proposed the idea of ​​using immune milk to control human diseases in 1955.

By the time Ralph Stolle moved his family to a large dairy farm in Lebanon, Ohio, in the 1950's, he had already become a wealthy industrialist. Stolle's career was based on innovative developments in aluminum fabrication and novel applications of that technology. His most far-reaching accomplishment was the development of high-speed presses for fabricating pop-top lids for aluminum beverage cans. The basic designs developed by Stolle's companies are still used today by beverage packagers worldwide.

As a consummate innovator, now dairy farmer, Stolle immediately began to seek novel applications and products to add value to milk. In this search, he ran across the work of Dr. William Petersen and colleagues at the University of Minnesota. Dr. Petersen demonstrated that the cow's mammary gland can produce vast quantities of antibodies against human diseases.

Dr. Petersen's contributions were significant because they focused attention on milk as an immunologically important substance. Mr. Stolle was intrigued by the health-enhancing potential of milk from cows immunized against human disease pathogens. He was particularly interested in the fact that Dr. Petersen's findings focused not only on classical infectious disease in humans but also on other conditions such as rheumatoid arthritis, hay fever, poison ivy, etc, depending on the immunization program. However, Dr. Petersen immunized the cows by intramammary infusion, a process that potentially contaminates the milk. Mr. Stolle objected to intramammary immunization and hired scientists to develop injectable immunogens. A proprietary immunization regimen and an immunogen consisting of killed bacterial cell wall antigens was developed, which came to be known as the "Series 100" (S100) immune stimulant.

From the very beginning, Mr. Stolle gave the milk away to friends and employees who requested it and asked that they report any perceived benefits on forms that were provided. Over the next three decades until Mr. Stolle's death in 1996, S100 skim milk powder was distributed at no charge in a study known as the "Ohio Survey". In the beginning, the majority of the participants in the Ohio Survey had rheumatoid or other forms of arthritis. Most recipients perceived improvement and continued to consume the equivalent of one quart of S100 skim milk daily for many months or even years. Over the years other health benefits such as cholesterol, blood pressure, heart ailments, muscle cramps, stomach ailments, etc. were also attributed to the consumption of S100 milk. Over the 35-year span of the Ohio Survey, records on over 8,000 participants were accumulated and the results were summarized.

It is readily apparent that the Ohio Survey was not a controlled study. Accordingly, Mr. Stolle hired scientists to conduct more formal investigations, including randomized, controlled clinical trials. One of the earliest of these was a double-blind, placebo-controlled, six-month crossover trial in subjects with rheumatoid arthritis. The study showed that there was a highly significant improvement in pain, disability, duration of morning stiffness, and reduction in medication use in people while on S100 milkS100 Milk compared to conventional skim milk. Scientists suspected that S100 milkS100 Milk may also express anti-inflammatory activity, which would help explain the observed relief of arthritis symptoms. Anti-inflammatory activity was later confirmed, patented, and is considered a core technology in SMBI ingredients. These findings above resulted in the issuance of over 200 patents and encouraged further research.

Immunonutrition is all about those immunonutrients, which not only cover the basic nutritional needs but it also modifies immune system function. Most importantly, all ImmunoNutrients should be demonstrated to support immunity by scientific and clinical studies.

Most immunonutrients support the immune system indirectly by providing the body and immune system with certain key nutrients such as certain amino acids, vitamins and minerals. In addition to the indirect immunonutritional support that immune milk provides, immune milk also contains complex bioactive immunonutrients that directly support a healthy immune system by balancing immune responses.

S100 Immune milk was developed and Inspired by the theory of maternal immunity in 1958 that goes a step further and redefines the meaning of "immunonutrition".For more than 60 years, S100 immune milk has been committed to quality control and optimization, S100 immune milk has more than 20 clinically proven health benefits and has won respect and recognition from scholars worldwide.

S100 immune milk has been developed into two health food ingredients: Immune Milk Powder (SMP) and Immune Milk Protein Concentrate (SMPC) which have been promoted to all over the world. We are committed to achieving every consumer's health promise and providing the best usage experience.